Endocrine Abstracts

The key factor in the pathogenesis of both T2D and NAFLD is insulin resistance, which causes the lipids accumulation in hepatocytes and an increase of the lipid peroxidation, the production of reactive oxygen species and the development of inflammation. It has been shown that the main metabolic products of the saccharolytic microflora-short-chain fatty acids (SCFA), such as acetic (Ac), propionic (Pr) and butyric (Bu), can have an anti-inflammatory effect through their suppres...

Introduction: The formation of oxidative stress in the biological reaction of inflammation is accompanied by the formation of methylglyoxal (MG), which initiates the glycosylation reaction of proteins. When hyperglycemia MG content significantly increased. MG interacts with the amino groups of lysine and arginine to form further glycation end products (CNG). Glycation is due to the ability of glucose to form irreversible chemical compounds of CNG with amino groups of proteins....

Introduction: Retinol binding protein (RSP) is a member of the adipokine family associated with insulin resistance (IR). With an excess of free fatty acids, the binding of insulin by hepatocyte receptors decreases and hyperinsulinemia develops. RSP is a transport protein for retinol, synthesized in hepatocytes and adipocytes. The level of RSP increased in patients with obesity, diabetes mellitus and non-alcoholic fatty liver disease (NAFLD) correlated positively with the sever...

Pathogenesis of Non-alcoholic fatty liver disease in 90% combined with diabetes mellitus (DM) of the second type. Factors cutting: abdominal obesity, excessive content of free fatty acids. Development of insulin resistance through protein kinase. Violation of the transmission of insulin signal leads to damage to the endothelium. Glycation of nitric oxide synthase leads to the development of diabetic complications and violates the sensitivity of the insulin receptors.<p cla...

Obesity affects on the composition of bile: the lithogenicity of bile increases, biliary sludge and cholelithiasis are developing. Under the influence of the active form of oxygen, abnormal forms of bile acids are formed, which negatively affects the development and progression of the pathological process. With the development of inflammation in the liver and pancreas, disturbances in the membrane proteins of glucose transporters occur, the activity of nuclear receptors for th...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes and non-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates t...

Methylglyoxal (MG) damages arginine protein residues, inhibits enzymes, disrupts insulin signal transmission, and plays a key role in the development of insulin resistance and hyperglycemia. High glucose levels cause an increase in glycation and methylglyoxal formation. Glycation is the main cause of protein damage, leading to the production of free radicals and causing inflammation.The purpose of the study: To Identify the relationship of methylglyoxal ...

Objective: To study the dynamics of cytolysis and carbonyl stress (methylglyoxal (MG)) in patients with type 2 diabetes mellitus (DM2) and non-alcoholic fat disease liver (NAFLD) on the background of various hypoglycemic therapy.Materials and methods: The study included 48 patients, 53.8 ± 11.14 years, with SD2 and NAFLD and 20 people in the control group. Viral hepatitis was excluded, toxic and drug-induced liver injury. Anthropometric researc incl...

Glycation is due to the ability of glucose to form irreversible chemical compounds with amino groups of lysine and arginine – methylglyoxal (MG).Material and Methods: 98 patients with NAFLD and 52 patients with NAFLD were examined. Diabetes 2-type, and 22 healthy volunteers. Age 57.3 ± 5.2 years. BMI 34.85 ± 1.79. The diagnosis was established on the basis of laboratory data and examination results. The level of LPO was determinedby the c...

Bile acids (BA) regulate glucose and lipid metabolism, provide bile flow, increase lipase activity by 10–15 times. With the development of inflammation, violations occur in the membrane proteins of glucose transporters.AimDetermine the total pool of bile acids in NAFLD with diabetes mellitus (DM) and impaired glucose tolerance (IGT). Determine the content of inflammation markers lipoprotein-associated phospholipase (Lp-PLA2), ...